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The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class

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Okumura, T

BPC-157 is derived from a gastric peptide fragment, TB-500 is a synthetic analog of thymosin beta-4 studied for actin-related processes, GHK-Cu is a copper-binding tripeptide frequently examined in extracellular matrix and biomarker research, and KPV is a short peptide fragment explored in preclinical settings for immunomodulatory signaling pathways

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