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Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

The gene-specific primer sequences are provided in Supplementary Table qPCR Primer section

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5 An abnormal increase in lipid content within muscle cells, hepatocytes, adipocytes, and in the circulation leads to inflammation and impaired insulin function through a number of potential pathways

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