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Long-term safety data remains limited for most of these compounds, so risks beyond short trials or animal studies are largely unknown

The agency said that it received reports of adverse events in people who used compounded semaglutide and that patients should not use a compounded drug if an approved drug is available. But the Outsourcing Facilities Association, a trade group representing companies that make certain compounded medications, has sued the FDA over its removal of tirzepatide from the shortage list claiming that it happened without notice, without soliciting input from affected parties and the public, and without meaningful rationale. Olympia Pharmaceuticals says that they provide compounded GLP-1 medications the vast majority of which are semaglutide to tens of thousands of patients each week, and there hasnt been sufficient reassurance for prescribers to feel confident that supply is strong enough to meet demand

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MOTS-c, used to treat metabolic conditions

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