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These medications carry a boxed warning about thyroid C-cell tumors (contraindicated with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings about potential risks including pancreatitis, gallbladder disease, acute kidney injury with dehydration, and worsening diabetic retinopathy with rapid glucose reduction (particularly with semaglutide)

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