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Side Effects of GLP- 1 Medications The effectiveness of GLP- 1 and dual GLP- 1/GIP receptor agonists in the treatment of obesity and overweight has been thoroughly established [143]

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Other downstream effects include reduced glutathione antioxidant levels leading to oxidative stress, increased intracellular calcium, and ER stress leading to protein aggregation of TDP-43, SOD1, and FUS [8, 311]