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Many patients remain on treatment for a year or longer
[Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]
GLP-1 was measured with a Glucagon-Like Peptide-1 (Active) ELISA kit (Millipore), and ghrelin in an automated enzyme immunoassay system (AIA-600 II Immunoassay Analyzer, TOSOH Bioscience)
This lack of benefit stands in contrast with the significant or nearly-significant reduction in macrovascular risk reported with liraglutide, semaglutide and exenatide [51,52,53], which also enhance signaling through the GLP-1 receptor [54]
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