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Figure 9: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis, respectively, based on severity of progression) is associated with decreased harvesting of energy and increased production of reactive oxygen species (ROS)

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Using standard wild-type mice to screen urate-lowering drugs introduces severe mechanistic biases

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Aging and neuroplasticity research: The documented effects on NGF receptor balance, BDNF upregulation, and microglial phenotype shifting are directly relevant to age-related brain changes