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Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats

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Therefore, the variation in IGFBPs expression is a crucial biomarker in breast tissue, for instance, high IGFBP-3 in TNBC is associated with poor prognosis, 103 while the loss of IGFBP-3, in vivo models, was associated with tumorigenic transformation

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This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis

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