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GLP-1 analogues promote the conversion of glucose to glycogen in the liver and muscles, with UDP-Glucose being a precursor of glycogen

Clinical Study Results (SURMOUNT & SURPASS) Tirzepatide has been evaluated in large phase 3 clinical studies in humans: Weight reduction: In the SURMOUNT studies, participants achieved up to 20.9% mean body-weight loss at the highest dose

Careful monitoring of blood sugar levels is essential

There have been no head-to-head studies to date comparing retatrutide with other incretins, and experts caution that owing to differences in clinical study designs and patient populations it is not appropriate to draw conclusions from cross-trial comparisons