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A large percentage of Americans are currently taking GLP-1 medications, and with such an increased interest, researchers have been examining other potential health benefits of these drugs outside of managing type 2 diabetes and weight loss
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Exendin-4 protects hypoxic islets from oxidative stress and improves islet transplantation outcome
Significant weight loss in the group treated with GLP-1RA was observed compared to the group got placebo in short-term (6 months) subgroup analysis
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There is also increased insulin degradation, and increased release of insulin precursors which is responsible for the shortening of the insulin half-life
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