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But ethics in healthcare cant rest on intent alone
2019;3(5):e10086
Weight loss associated with vagus nerve stimulation
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Next steps in clinical translation First-in-human safety trials (phase I) are essential: to assess dose tolerability, pharmacokinetics, biodistribution, peptide half-life, clearance, immunogenicity
TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development
Resveratrol, a natural activator of SIRT1, can deacetylate and activate key transcription factors, reducing oxidative stress and promoting mitophagy (Table 2)
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