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reported that serum HGF levels were increased after PHx, which was associated with hepatocellular dysfunction, necrosis, and systemic inflammation (Tomiya et al., 1992)

Drugs 74 , 929938 (2014)

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If gastrointestinal symptoms significantly impair quality of life or prevent medication adherence despite conservative management, healthcare providers may consider dose adjustment, alternative agents with potentially different side effect profiles, or referral to a gastroenterologist for specialized evaluation

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