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As an endogenous human tripeptide used topically for decades in skincare, GHK-Cu is generally regarded as well tolerated, with the most common issues being local irritation, redness, or contact sensitivity in susceptible individuals

There has been one report of an allergic reaction to-date

Researchers first extracted a peptide preparation known as Epithalamin from bovine pineal tissue, which is biological material harvested from the pineal glands of cattle

[PMID: 14879083] PubMed record related to this compound for laboratory literature review

PMC 1133600

Also, GSH can be determined the quantity by subtracting GSSG from the total amount of glutathione