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While it has not yet received FDA approval, it remains a keen interest among scientists

A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes (p=0.270)

Pract Gastroenterol, 44 (44), 34-9

Secondary recanalization after lysis of the clots which cause obstruction early in the reaction, and the subsequent bleeding after several weeks, could explain why foam-sclerosed veins fill up again with blood around the 6th week