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Saxenda is not recommended for people with severe gastroparesis (delayed stomach emptying), as it further slows the movement of food through the stomach
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Mechanistically, it acts systemically: it sequesters G-actin, promotes endothelial cell migration in scratch-wound assays, and has shown progenitor-cell mobilization signals in preclinical cardiac models
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In response to increased insulin resistance, the pancreas compensates by secreting higher levels of insulin, resulting in hyperinsulinemia
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