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Some clinical studies have suggested that GLP-1 receptor agonists may have a modest uric acid-lowering effect

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We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase (AMPK), which activates the downstream transcription factors PGC-1, PGC-1, or FOXO1 for mitochondrial biogenesis