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Cureus 11 , e5810 (2019)

Should be used with caution in patients with a history of gastrointestinal disorders, as it may exacerbate symptoms

[2] [3] There is limited research on berberine's effects during pregnancy or lactation, and women who are pregnant, planning pregnancy, or breastfeeding should consult their GP, midwife or pharmacist before using any berberine products

GIP Agonism Reduces appetite, nausea, and bone resorption Increases insulin & glucagon production, and lipogenesis Glucagon Agonism Reduces appetite, food intake, and gastric emptying Increases insulin production, energy expenditure, and nausea Amylin Agonism Reduces appetite, food intake, glucagon production, and gastric emptying Increases energy expenditure Reduces bone resorption and increases bone production PYY Agonism Reduces appetite, food intake, and gastric emptying Increases energy expenditure and nausea The Cost Challenge for Payers The cost of GLP-1s continues to be a significant concern for payers between skyrocketing costs and utilization over the past several years

But as far as I know, almost every study showing those benefits was sponsored by DuPont Nutritionwho also happens to be the worlds largest supplier of betaine