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Hwee, Y

Hardwired meaning that it's there and it's immutable, it cannot be changed

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Microsomal prostaglandin E 2 synthase-1 (MPGES-1), a member of the MAPEG family, is implicated in the biosynthesis of prostaglandin E 2 a metabolite of arachidonic acidinvolved in several biological functions

For the enzyme activation, the YxxL sequences must be spaced apart to engage both of the SH2 domains of Syk family kinase (Figure 5)

nevertheless, a recent study has reported that this enzyme could be considered as an independent prognostic factor in colorectal cancer patients 52