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Peptides 151:170749 McGregor G, Harvey J (2018) Food for thought: leptin regulation of hippocampal function and its role in Alzheimers disease
Moreover, in addition to showing the direct inhibition of GAPDH by oxidation, the authors demonstrated that its activity is further hindered by DHA-induced NAD + depletion, since GAPDH activity relies on the availability of NAD + as a co-substrate
It's a small chemical molecule, but without the protein
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