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Timing and frequency considerations: Start with smaller servings (100150ml) and gradually increase as tolerated, rather than consuming a full shake immediately Consider splitting your protein intake across multiple smaller servings throughout the day rather than one large shake Consume protein shakes between meals rather than with solid food to avoid overwhelming the digestive system Adjust timing based on your individual responsesome people find protein shakes more tolerable at certain times of day or in relation to their Ozempic injection Preparation recommendations: Mix protein powder with water or unsweetened almond milk rather than full-fat dairy, which may worsen nausea Blend thoroughly to ensure smooth consistency, as lumps may be less palatable when appetite is reduced Serve chilled or over ice, as cold temperatures can help reduce nausea Avoid adding high-sugar fruits or sweeteners that could impact glycaemic control Safety precautions: Patients should monitor for signs of intolerance, including increased nausea, vomiting, abdominal pain, or diarrhoea

doi: 10.1016/j.diabres.2021.109119 33 PoriesWJMacdonaldKGJr.FlickingerEGDohmGLSinhaMKBarakatHAet al