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In contrast, we found TGF-induces the lactylation of USP2, but not the expression of USP2, in TECs (Fig

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Unlike apelin or spexin, METRNLs receptor has not yet been definitively identified, placing it among ligands whose translational development is constrained by incomplete mechanistic understanding

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[1] [2] It works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

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