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Glucagon increases heart rate & cardiac output/contractility while lowering pulmonary vascular resistance

22% weight loss at 36 weeks with no plateau is strong, but Phase 3 at longer durations will tell us where it truly lands

The clinical program involving the triple agonist retatrutide will uniquely be utilizing a basket trial format A basket trial is a type of clinical trial that evaluates the effect of a single drug across multiple disease states that share a common feature, in this case obesity A basket design nests under a single master protocol multiple subtrials, or baskets, each with its own population, endpoints and analysis plan

Retatrutide is not started at the maintenance dose

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Platelet-rich plasma (PRP) or growth factor treatments for additional growth factors