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While weight loss plays a role, researchers believe these medications may also directly improve blood vessel function and reduce inflammation

Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN3): a 56-week, open-label, randomized clinical trial

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However, the clinical reality is that heavier individuals may need to reach higher doses to achieve comparable appetite suppression effects

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Cancer Res (2008) 68(23):974653