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Although both live and pasteurized Akkermansia have been proven to be well tolerated in humans, pasteurized Akkermansia is able to increase beneficial effects
Secondary outcomes included progression to permanent AF defined as a clinical diagnosis coded by the treating physician ( International Classification of Diseases code I48.2) where both the patient and physician have agreed to manage the condition with rate control rather than attempting cardioversion, all-cause mortality, hospitalization for heart failure, cardiovascular-related hospitalizations, repeat ablation procedures, atrioventricular node ablation, and a composite of cardioversion or amiodarone initiation
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Live biotherapeutic products: the importance of a defined regulatory framework
