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Interestingly, the Sisley group generated mice with glutamatergic neuronal deletion of GLP-1R and observed that GLP-1R agonists successfully execute glucose-lowering effects but fail to induce weight loss (Sisley et al., 2014), suggesting that the brain may control the anti-obesity actions of GLP-1

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Sharon Barr, executive vice president, biopharmaceuticals R&D at AstraZeneca, said, Building on the promising Phase I clinical data generated by Eccogene, we believe this oral GLP-1RA molecule could offer alternatives to current injectable therapies both as a potential monotherapy as well as in combination for cardiometabolic diseases such as type 2 diabetes, as well as for obesity

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That said, we're still learning about long-term effects, so continued monitoring is still encouraged