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The analysis, titled Are All Incretin Therapies Equal for the Kidney
This is why many traditional oral supplements yield disappointing results
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( Glycemic Control Compared to maintaining GLP-1RA, both strategies of adding basal insulin (i.e., free-up titration of basal insulin or switching to FRC) effectively decreased HbA1c from baseline to week 26 (free up-titration, WMD 0.71%, 95% CI 1.05 to 0.37
(2) Advantages Over Synthetics : Natural agonists often exhibit fewer gastrointestinal side effects and additional benefits (e.g., anti-inflammatory, lipid-lowering), though their efficacy and half-life are inferior to drugs like semaglutide
10.1038/s41419-021-03669-w 2 BanachM.SerbanC.SahebkarA.UrsoniuS.RyszJ.MuntnerP.et al (2015)
