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Statistical differences among treatments were assessed using either a parametric one-way ANOVA (anatomical measurements, ERGs) followed by a Tukey posthoc test, or a nonparametric Kruskal-Wallis (H) test (optomotor responses) followed by Dunns test to identify the source of the significance

The mean time to intensification of treatment with insulin was 7.1, 6.1 and 6.0 years for those taking one, two or three oral drugs

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