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Much research is also being done with these two peptides in the setting of traumatic brain injury, stroke, and neurodegenerative diseases like ALS and Alzheimers.

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The reasons for a link between vitamin B 12 deficiency and depression are not clear but may involve a shortage in S-adenosylmethionine (SAM)

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Although B-vitamin supplementation lowers blood homocysteine levels in older subjects, the long-term benefit is not yet known