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10.1371/journal.pone.0102356 PLoS One 123 LiS.Koziol-WhiteC.JudeJ.JiangM.ZhaoH.CaoG.et al (2016)
Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity: a post hoc analysis of the SURMOUNT-4 trial
Indeed, liraglutide is thought to acutely suppress food intake by activating GABAergic GLP-1R-expressing DMH neurons which project to and inhibit ARC AgRP/NPY neurons as determined by patch-clamp electrophysiology experiments on hypothalamic slices [129]
It is important to note that whilst some preliminary evidence exists, natural supplements are not substitutes for prescribed medications and should not be used as such without medical guidance
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