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PLoS ONE 8 , e72067 (2013)

In AD models and postmortem brain samples, GSH levels are consistently reduced, indicating that redox instability contributes to disease progression

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In terms of treatments, epigenetic therapy, including treatment with DNA methyltransferase and histone deacetylase inhibitors (DNMTis and HDACis, respectively), can increase the numbers of CD45 + immune cells, active CD8 + T cells and NK cells in the TME, reducing immunosuppression and the tumor burden through activation of type I interferon signaling in murine ovarian cancer [171, 172]

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Formulation Stability and Bioavailability Challenges Retinol is notoriously unstable in formulation