However, high doses may not provide extra benefits and should be avoided
For most people, the body responds by releasing insulin, which helps move sugar from your blood into your cells, where it can be used for energy
Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)
Efferocytosis of apoptotic cells is well documented to create an immunosuppressive and inflammation-resolving microenvironment, reprogramming macrophages [239, 240]
The chart below shows the expected mortality impact of these scenarios at the population level
PubMed laboratory research record [PMID: 9736316] PubMed record related to this compound for laboratory literature review