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SAM's many roles: SAM is the primary methyl donor, used in DNA/RNA methylation, protein modification, and synthesis of neurotransmitters and hormones
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Research has examined NNMT inhibition and its downstream effects on cellular NAD+ salvage, methylation balance and adipocyte energy metabolism, with preclinical work exploring roles in lipid handling and metabolic regulation
Serious adverse effects are rare but have been reported, particularly with IV administration of thiamine
Carvalho, C
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