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When the inflammatory burden is high from insulin resistance, dyslipidemia (high LDL/triglycerides), high blood pressure, and liver stress it drives cholesterol particles into the artery lining and triggers the plaque buildup that can eventually rupture and cut off blood flow to the heart

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2022, NEJM) showed 20.9 percent weight loss at 72 weeks, the primary clinical reference OptumRx uses when evaluating medical necessity

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