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Assessment of inter-and intra-subject data quality was accomplished by comparing fit errors (calculated as the s.d

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Mice exposed to Epithalon exhibited 30-45% higher activation of fibroblasts than controls

In DKD, continuous activation of RAAS leads to elevated pressure within the glomeruli, enhances the production of ROS, promotes tissue damage, triggers the release of proinflammatory cytokines, and stimulates the development of fibrosis in the glomeruli and tubulointerstitium