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Unlike oral supplements, the injectable form delivers glutathione directly into tissue, which may help support more consistent absorption
Mechanism of Action Enzymatic Protection Mechanism : The phenylacetyl group acts as a protective shield that redirects glutathione-degrading enzymes away from the core glutathione molecule, forcing these enzymes to cleave the phenylacetyl group instead and releasing active glutathione intracellularly
The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)
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we consider intervention in the next section
