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Its downstream signaling through PI3K/Akt/mTOR and MAPK/ERK makes it relevant to a wide range of research questions in muscle biology, bone physiology, neuroprotection, and metabolic signaling
The proline substitutions at positions 25, 28, and 29 were specifically engineered to suppress the beta-sheet aggregation pathway that destabilises native human amylin in aqueous solution
Inflammatory cell infiltration follows tissue injury, initially serving protective functions but potentially causing secondary damage if prolonged or excessive
doi:10.1007/s12020-017-1446-7
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