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Note that a dipeptidyl peptidase 4 (DPP-4) inhibitor can be discontinued when adding GLP-1RA because they are both incretin-based therapies and the DPP-4 inhibitor is redundant in that situation

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Although danuglipron showed good weight loss in phase II trials, the drug was discontinued when a trial participant suffered liver damage

While there is no universal answer on if or when to choose bariatric surgery after GLP-1s, there are clear clinical signals that a conversation about surgery is worth having

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