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doi: 10.1038/s41420-025-02617-3 175 BersukerKHendricksJMLiZMagtanongLFordBTangPHet al

Semaglutide is an exceptionally powerful metabolic tool, but it functions best when paired with a balanced, protein-rich diet and regular physical activity to preserve lean muscle tissue while maximizing fat loss

Studies have examined its effect on cell migration and blood vessel formation, which are important factors in tissue recovery models

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While there is potential mechanistic overlap with DPP-4 inhibitors or dual GLP/GIP receptor agonists we focus the current review on GLP-1RAs due to preponderance and availability of longer-term data, as well as the significantly higher market penetrance of this drug class