Retatrutide (LY3437943) is a first-in-class triple-receptor agonist peptide developed by Eli Lilly that simultaneously activates three metabolic receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon
Drug Interactions and Compatibility 9.1 Interaction with Insulin and Oral Antidiabetics Concomitant use may require dose adjustments to prevent hypoglycemia
The APOE-TR model is a mouse knock-in model where exons 24 (comprising the mouse APOE gene) are replaced with human APOE in 129xC57BL/6 mice back-crossed to C57BL/6 mice (Sullivan et al., 1997)
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10.1038/sj.emboj.7600178 63 Saint-JeanA