Using metabolomics, we analyzed the metabolic changes and molecular characteristics in the auditory cortex, revealing a notable enrichment of oxidative stress-related pathways in tinnitus-affected mice
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Interestingly, a few years ago it has been published that in flies missense mutations of the SLC25A39 homologue shawn results in accumulation of ROS as well as in mitochondrial dysfunction, synaptic defects, and neurodegeneration
However, a significant decrease in cell viability was observed when these compounds were used at 10,000 M, indicating their cytotoxic effect
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