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Class B GPCRs typically bind their peptide ligands through a mechanism known as the two-domain model, in which ECD binds to the C-terminal helix of GLP-1, and the transmembrane domain (TMD) binds to the N-terminal region of GLP-1 (3, 4, 5)

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doi: 10.1016/j.jep.2024.119256 32 LiuXWuHRenZWangYYangGCongHet al

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The results showed that all doses (5mg, 10mg and 15mg/weekly) had a greater effect on glycemic control and glycated hemoglobin (HbA1c) levels when compared to placebo or the GLP-1 receptor agonist