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Due to the diversity of its pharmacological activities, including anti-inflammatory[254], immunoregulatory[272], and anti-depressive effects[238], paeoniflorin is widely used in the treatment of various diseases

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For example, supplementation with GSH increased active drug efflux in E

Selective permeability: Small lipophilic molecules pass relatively freely

How Nasal Delivery Bypasses the Blood-Brain Barrier Through nasal inhalation, therapeutic compounds can reach the brain in minutes without passing through the bloodstream first

doi: 10.3389/fbioe.2021.677576 Received 07 March 2021 Accepted 12 April 2021 Published 29 April 2021 Volume 9 - 2021 Edited by Zhen Li, AO Research Institute, Switzerland Reviewed by Guangli Suo, Suzhou Institute of Nano-tech and Nano-bionics (CAS), China