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The SURPASS-J-combo trial embraced diabetic adults with HbA 1c 7% to 11% and BMI 23 kg/m 2 , stable weight and uncontrolled with therapy of metformin, thiazolidinedione, sulfonylureas, meglitinide, alpha-glucosidase inhibitor or SGLT2-i (81)
Specifically, GLP-1 Agonist works through the following mechanisms: Appetite suppression GLP-1 Agonist activates areas of the brain that reduce appetite and promote feelings of fullness
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