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A separate 2025 trial in NEJM Evidence (Shah et al.) in adults with T1D and obesity on AID found that around one in three semaglutide-treated participants met a combined goal of improved time in range, low hypoglycemia, and at least 5% weight loss
That single action prolongs the sense of fullness, but it is also the direct source of the characteristic gastrointestinal side effects of the GLP-1 class, from nausea to constipation
There have not been any large, long term studies to show the safety and efficacy of intravenous glutathione
