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Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability

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This includes, at a minimum, fasting blood glucose and ideally IGF-1 levels to ensure they remain within a safe and effective range for the study's objectives

Adequate protein intake provides amino acids for collagen synthesis and tissue rebuilding

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