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* In Alzheimers Disease: a mechanistic study found that methylene blue oxidizes cysteine sulfhydryl groups on tau to keep tau monomeric
Sporadic application doesn't deliver cumulative signaling effects
Typical daily dose: 6001000 mcg total (300500 mcg of each peptide)
What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data
A clinical interview by a trained team member using a standardized symptom assessment was video-recorded (SA4)
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