185,194,195 The interaction of BAs and intracellular FXR not only inversely regulates BA synthesis, but inhibits hepatic adipogenesis and steatosis, reduces hepatic gluconeogenesis, and increases peripheral insulin sensitivity through transcription of GLUT4
In clinical trials of semaglutide tablets for T2DM, cholelithiasis was reported in 1% of patients-treated with semaglutide 7 mg tablets
Watch-out: D+ BBB rating, though likely driven by complaint volume during rapid growth rather than systematic issues
Hamza M, Papamargaritis D, Davies MJ
2 Overall, tirzepatide provided superior glycemic control and more pronounced weight reduction compared to semaglutide, while maintaining a comparable safety and tolerability profile
In my case, it has definitely supported general wellbeing, and that is certainly very valuable in itself.