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Indeed, most studies do not incorporate sex as a discovery variable, and thus, in only a small proportion of studies, sex is used as a predictor variable or a between-subject variable to analyse for main and interaction effects rather than as a covariate [238, 239]
Whilst nightmares and vivid dreams are not listed as recognised adverse effects in the Summary of Product Characteristics (SmPC) or MHRA guidance, some patients have reported sleep disturbances during treatment
Several forces can cause that
That is why side effects often peak during titration and settle down later
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The mechanisms driving these effects are multifaceted, involving the suppression of neuroinflammation via the TLR4/NF-B pathway and restoration of brain energy metabolism through the activation of the AMPK and SIRT1/GLUT4 signaling cascades (Wang et al., 2023
