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Before the pandemic, several reports documented that certain mask types can increase inhaled CO 2 concentrations, occasionally approaching or exceeding occupational exposure limits for acute (3% for 15 min) or chronic (0.5% for 8 h) inhalation ( 2 exposure involves acute ventilatory changes, with 1%2% CO 2 inhalation inducing an approximately 34% rise in minute ventilation ( 2 accumulation surpasses compensatory capacity, respiratory acidosis may occur, triggering renal bicarbonate retention and increased H + excretion to restore acidbase balance ( 2 have also been described ( However, contemporary literature reveals conflicting findings regarding the physiological impact of mask-related CO 2 accumulation
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