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Examples include other biologics such as Humira (adalimumab), immunoregulators such as Otezla (apremilast), and less costly immune suppressants such as methotrexate

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Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts

doi: 10.1080/15548627.2020.1725377 145 TangCLivingstonMJLiuZDongZ

Whether this is clinically preferable to more frequent, pulse-preserving dosing with Mod GRF 1-29 depends on the treatment objective a point worth discussing with a prescribing clinician